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Pim-2 phosphorylation of p21 Cip1/WAF1 enhances its ...

Pim-2 kinase is one of three highly conserved Pim family members which are known to be involved in cell survival and cell proliferation. Here we demonstrate that like Pim-1, Pim-2 also phosphorylates the cell cycle inhibitor p21 Cip1/WAF1 (p21) on Thr145 in vitro and in vivo.Overexpression of Pim-2 in HCT116 cells leads to the increased stability of p21, and results in enhanced levels of both ...

Prognostic Impact of Jab1, p16, p21, p62, Ki67 and Skp2 in ...

p21 (Waf1) is a cell cycle regulator, implicated in a variety of pathways ... In the multivariate analysis, age (P = 0.012), malignancy grade (P<0.001) and wide resection margins (P = 0.001) were independent prognostic factors for DSS. In addition, Skp2 had an independent prognostic impact in women (P = 0.009) and in patients not treated with chemotherapy or radiation (P = 0.026). Table 6 ...

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p53, mdm2, and p21 expression in oral squamous cell ...

Combined p53/mdm2/p21 expression cases and lack of combined p53/mdm2/p21 expression cases (P =.012) (C). Discussion. Understanding the p53 pathway of oral carcinogenesis may help better predict the biologic behavior and select the appropriate management strategy. Previously, it has been indicated that alteration of the p53 pathway is a crucial key event in determining the biologic behavior of ...

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The prognostic significance of p21 and Her-2 gene ...

Analyses of gene expression status and genetic polymorphisms are methods to identify novel histopathological prognostic factors. In patients with gastric cancer, some cell cycle regulators p53, p21, p27 and Her-2 oncogene have been proposed as prognostic factors. We aimed to investigate the expression and mutation/polymorphism of p21 and Her-2 and also relationship between that genes status ...

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Translational Upregulation of an Individual p21 Cip1 ...

Introduction. p21 Cip1, a member of the CIP/KIP family of cell cycle inhibitors, is known to play a key role in regulating the transition from G 1 to S phase of the cell cycle. Under normal conditions, complexes of cyclin E and cyclin dependent kinase 2 (CDK2) are active in late G 1 phase and phosphorylate the retinoblastoma protein (pRb). ). Phosphorylated pRB dissociates from E2F ...

IGFBP-rP1 induces p21 expression through a p53-independent ...

Knockdown of p53 in MCF-7 cells did not influence the growth inhibition, cellular senescence, and p21 expression of the cells in response to IGFBP-rP1 transfection. Results from this study suggest that cellular senescence induced by IGFBP-rP1 is mediated at least in part by p21 enhanced expression, which regulated through the p53-independent pathway. IGFBP-rP1 might be one of the key molecules ...

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PAK1-dependent MAPK pathway activation is required for ...

P21-activated protein kinase1 (PAK1), a main downstream effector of small Rho GTPases, Rac1, and Cdc42, plays an important role in the regulation of cell morphogenesis, motility, mitosis, and angiogenesis. Despite its importance, the molecular mechanisms of PAK1 that contributed to colorectal carcinogenesis remain unclear. Our immunohistochemistry showed that PAK1 expression was increased with ...

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